TY  - JOUR
PY  - 1999//
TI  - The predictive value of benzodiazepine tolerance in persistently aggressive schizophrenia
JO  - Neuropsychobiology
A1  - Hatta, K.
A1  - Takahashi, Toru
A1  - Nakamura, Hideki
A1  - Yamashiro, H.
A1  - Endo, H.
A1  - Kito, K.
A1  - Fujii, S.
A1  - Matsuzaki, I.
A1  - Masui, K.
A1  - Yonezawa, Y.
SP  - 196
EP  - 199
VL  - 39
IS  - 4
N2  - The aim of this study was to determine whether benzodiazepine tolerance might provide a predictive marker for persistent aggression in schizophrenia. Seventy-seven male schizophrenic patients newly admitted to our psychiatric intensive care unit due to violent behavior during a 4-month period were examined. As a result, a high dose of benzodiazepine required for sedation or a short duration until regaining consciousness after the initial sedation, was related to severer aggression on waking up after sedation. Despite the small number of subjects examined, a conservative claim can be made that the level of the effect of benzodiazepine required for sedation seems to predict persistent severe aggression in schizophrenia.<p /> <p>Language: en</p>
LA  - en
SN  - 0302-282X
UR  - http://dx.doi.org/
ID  - ref1
ER  -