TY  - JOUR
PY  - 1999//
TI  - Propranolol treatment of chronically hospitalized aggressive patients
JO  - Journal of neuropsychiatry and clinical neurosciences
A1  - Silver, J. M.
A1  - Yudofsky, S. C.
A1  - Slater, J. A.
A1  - Gold, R. K.
A1  - Stryer, B. L.
A1  - Williams, D. T.
A1  - Wolland, H.
A1  - Endicott, J.
SP  - 328
EP  - 335
VL  - 11
IS  - 3
N2  - Violent behavior in psychiatric patients may result in long-term hospitalization. There is no FDA-approved psychopharmacologic treatment for aggression. In this study, 20 chronically aggressive hospitalized patients were administered 1 week of placebo followed by an open trial of increasing doses of propranolol. Patients who had an equivocal or definite clinical response were entered into an open add-on double-blind discontinuation study phase. Aggressive behavior was objectively documented throughout the study. After the open phase of the study, 7 patients had a greater than 50% decrease in aggressive behavior. Four patients entered the double-blind discontinuation phase. The clinical course of 3 of those patients was consistent with the positive response to propranolol. The results of this study are consistent with a therapeutic effect of propranolol in some patients with aggressive behavior. Further studies are indicated.<p /> <p>Language: en</p>
LA  - en
SN  - 0895-0172
UR  - http://dx.doi.org/
ID  - ref1
ER  -