TY  - JOUR
PY  - 1999//
TI  - Estrogen therapy and aggressive behavior in elderly patients with moderate-to-severe dementia: results from a short-term, randomized, double-blind trial
JO  - American journal of geriatric psychiatry
A1  - Kyomen, H. H.
A1  - Satlin, A.
A1  - Hennen, J.
A1  - Wei, J. Y.
SP  - 339
EP  - 348
VL  - 7
IS  - 4
N2  - The authors used a randomized, double-blind, placebo-controlled clinical trial study design to investigate the efficacy and safety of short-term estrogen therapy in decreasing aggressive behaviors in elderly patients with moderate-to-severe dementia. Estrogen therapy was associated with lower total aggression scores (P<0.030) and with decreased frequency of physical aggression (P<0.019) over the 4-week trial. Verbally aggressive behaviors were decreased relative to control subjects, although this effect was not statistically significant. No drug-vs.-placebo differences were found for resistive, sexual, or self-directed aggressive behaviors. No adverse effects from the estrogen were observed during the course of the study.<p /> <p>Language: en</p>
LA  - en
SN  - 1064-7481
UR  - http://dx.doi.org/
ID  - ref1
ER  -