TY - JOUR PY - 2008// TI - Dissocial behavior, the 5HTTLPR polymorphism, and maltreatment in women with bulimic syndromes JO - American journal of medical genetics. part B, neuropsychiatric genetics A1 - Steiger, Howard A1 - Richardson, Jodie A1 - Joober, Ridha A1 - Israël, Mimi A1 - Bruce, Kenneth R. A1 - Ng Ying Kin, N. m.k A1 - Howard, Heidi A1 - Anestin, Annelie A1 - Dandurand, Cathy A1 - Gauvin, Lise SP - 128 EP - 130 VL - 147B IS - 1 N2 - We recently reported that, among bulimic women, previously abused carriers of the 5HTTLPR S allele showed special propensities towards novelty seeking (implying recklessness or impulsivity) and interpersonal insecurity. We subsequently re-analyzed our data, to examine the bearing of the 5HTTLPR polymorphism and prior sexual or physical maltreatment upon validated, higher-order personality-traits. Ninety women with bulimic syndromes were genotyped for 5HTTLPR “short” (S) and “long” (LG and LA) alleles, and then assessed for eating symptoms, history of sexual or physical abuse, and the higher-order personality traits Emotional Dysregulation, Dissocial Behavior, Inhibition, and Compulsivity. With a classification based on a biallelic model of 5HTTLPR (i.e., presence or absence of at least one S-allele copy), multiple regression indicated a significant proportion of variance in Dissocial Behavior to be explained by an abuse × genotype interaction—greater psychopathology occurring in abused S-allele carriers. A parallel analysis applying a triallelic model of 5HTTLPR (i.e., presence or absence of at least one copy of presumably low-function S or LG alleles) produced a similar pattern, but no statistically significant effect. The finding that bulimic 5HTTLPR S-allele carriers who are previously abused display elevations on Dissocial Behavior corroborates previous observations concerning phenomenological correlates of traumatic stress in 5HTTLPR S allele carriers. © 2007 Wiley-Liss, Inc.

LA - SN - 1552-4841 UR - http://dx.doi.org/10.1002/ajmg.b.30579 ID - ref1 ER -