TY  - JOUR
PY  - 2008//
TI  - Protein Kinases and Addiction
JO  - Annals of the New York Academy of Sciences
A1  - Lee, Anna M.
A1  - Messing, Robert O.
SP  - 22
EP  - 57
VL  - 1141
IS  - 1
N2  - Although drugs of abuse have different chemical structures and interact with different protein targets, all appear to usurp common neuronal systems that regulate reward and motivation. Addiction is a complex disease that is thought to involve drug-induced changes in synaptic plasticity due to alterations in cell signaling, gene transcription, and protein synthesis. Recent evidence suggests that drugs of abuse interact with and change a common network of signaling pathways that include a subset of specific protein kinases. The best studied of these kinases are reviewed here and include extracellular signal-regulated kinase, cAMP-dependent protein kinase, cyclin-dependent protein kinase 5, protein kinase C, calcium/calmodulin-dependent protein kinase II, and Fyn tyrosine kinase. These kinases have been implicated in various aspects of drug addiction including acute drug effects, drug self-administration, withdrawal, reinforcement, sensitization, and tolerance. Identifying protein kinase substrates and signaling pathways that contribute to the addicted state may provide novel approaches for new pharmacotherapies to treat drug addiction.<p /> 
LA  - en
SN  - 0077-8923
UR  - http://dx.doi.org/10.1196/annals.1441.022
ID  - ref1
ER  -