TY  - JOUR
PY  - 2008//
TI  - Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: A preliminary study
JO  - American journal of medical genetics. part B, neuropsychiatric genetics
A1  - Biederman, Joseph
A1  - Kim, Jang Woo
A1  - Doyle, Alysa E.
A1  - Mick, Eric
A1  - Fagerness, Jesen
A1  - Smoller, Jordan W.
A1  - Faraone, Stephen V.
SP  - 1511
EP  - 1518
VL  - 147B
IS  - 8
N2  - A growing body of literature finds gender differences in ADHD. However, little is known about the causes of these differences. One possibility is that ADHD risk genes have sexually dimorphic effects. We have investigated four ADHD candidate genes (COMT, SLC6A2, MAOA, SLC6A4) for which there is evidence of sexually dimorphic effects. Past neurobiological and genetic studies suggest that COMT, and SLC6A4 variants may have a greater influence on males and that SLC6A2, and MAOA variants may have a greater influence on females. Our results indicate that genetic associations are stronger when stratified by sex and in the same direction as the previous neurobiological studies indicate: associations were stronger in males for COMT, SLC6A4 and stronger in females for SLC6A2, MAOA. Moreover, we found a statistically significant gender effect in the case of COMT (P = 0.007) when we pooled our work with a prior study. In conclusion, we have found some evidence suggesting that the genetic association for these genes with ADHD may be influenced by the sex of the affected individual. Although our results are not fully validated yet, they should motivate further investigation of gender effects in ADHD genetic association studies. © 2008 Wiley-Liss, Inc.<p /> 
LA  - 
SN  - 1552-4841
UR  - http://dx.doi.org/10.1002/ajmg.b.30874
ID  - ref1
ER  -