TY - JOUR PY - 1994// TI - Total cholesterol and suicidality in depression JO - Biological psychiatry A1 - Sullivan, P. F. A1 - Joyce, P. R. A1 - Bulik, C. M. A1 - Mulder, R. T. A1 - Oakley-Browne, M. SP - 472 EP - 477 VL - 36 IS - 7 N2 - There exists considerable controversy regarding an association between low total cholesterol and increased mortality from suicide. As suicide mortality is a crude marker for suicidal ideation and behavior, we investigated the association between total cholesterol and suicidality in a depressed sample. Ninety men and women meeting structured criteria for a major depressive episode of at least moderate severity participated in a study of predictors of treatment response. A three level variable codified the degree of suicidality in the previous month: no suicidal thoughts (39/90), suicidal ideation or plan (38/90), and a suicide attempt (13/90). There was a significant univariate association between lower cholesterol levels and increasing degrees of suicidality. In a multivariate analysis, this association was the only one that neared statistical significance (p = 0.068). Although it is premature to conclude that these variables are causally associated, data from a number of sources suggest that this association is worthy of further study.

Language: en

LA - en SN - 0006-3223 UR - http://dx.doi.org/ ID - ref1 ER -