TY  - JOUR
PY  - 1996//
TI  - Cerebral uric acid increases following experimental traumatic brain injury in rat
JO  - Brain research
A1  - Tayag, E. C.
A1  - Nair, S. N.
A1  - Wahhab, S.
A1  - Katsetos, C. D.
A1  - Lighthall, J. W.
A1  - Lehmann, J. C.
SP  - 287
EP  - 291
VL  - 733
IS  - 2
N2  - Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-8993
UR  - http://dx.doi.org/
ID  - ref1
ER  -