TY  - JOUR
PY  - 2011//
TI  - Age-related changes in short-interval intracortical facilitation and dexterity
JO  - Neuroreport
A1  - Clark, Jordana
A1  - Loftus, Andrea
A1  - Hammond, Geoff
SP  - 499
EP  - 503
VL  - 22
IS  - 10
N2  - Functional changes in the primary motor cortex might contribute to age-related decline in fine motor control. We measured short-interval intracortical facilitation (SICF) in an intrinsic hand muscle with paired-pulse transcranial magnetic stimulation at interstimulus intervals (ISIs) of 1.5, 2.5, and 4.5 ms in young and old participants and examined its association with dexterity. We found age-related effects in SICF, with greater facilitation in old than young participants at the 1.5-ms ISI and greater facilitation in young than old participants at the 2.5-ms ISI. SICF at the 2.5-ms ISI was positively correlated with performance on a task that required coordinated and dextrous use of both hands, suggesting that this measure indicates a capacity for executing demanding manual tasks.<p />  <p>Language: en</p>
LA  - en
SN  - 0959-4965
UR  - http://dx.doi.org/10.1097/WNR.0b013e3283487480
ID  - ref1
ER  -