TY  - JOUR
PY  - 2004//
TI  - Possible alterations in brain neural network by ethanol
JO  - Nihon Arukoru Yakubutsu Igakkai Zasshi
A1  - Yamamoto, Megumi
A1  - Ukai, Wataru
A1  - Tateno, Masaru
A1  - Saito, Toshikazu
SP  - 51
EP  - 60
VL  - 39
IS  - 1
N2  - Advances in the neurosciences over the past two decades have elucidated that alcoholism is a chronic and easily recurring disorder, which is based on brain damage induced by long-term ethanol consumption. Researchers have identified neural circuits that subsume the actions of ethanol and they have also elaborated many of the intracellular signalling pathways that follow receptor activation by ethanol, suggesting a substantial difference between the addicted brain and non-addicted brain. However, most of the molecular biological changes, which are likely based on the transition from occasional drinking to alcohol dependence, remain to be elucidated. This review summarizes the findings on the biological background of alcoholism concerning the brain rewarding system, its related receptors, and the second messenger-mediated signal transduction system within the cells, especially focusing on the cyclic AMP signaling pathway calcium (Ca2+) system in neurons. In addition, our studies with neural stem cells are introduced to indicate future directions of research on the pathophysiology of alcoholism.<p /> <p>Language: ja</p>
LA  - ja
SN  - 1341-8963
UR  - http://dx.doi.org/
ID  - ref1
ER  -