TY  - JOUR
PY  - 2002//
TI  - Clinical study of BRON-L syrup (cough suppressant) abuse
JO  - Nihon Arukoru Yakubutsu Igakkai Zasshi
A1  - Miyatake, Ryosuke
A1  - Doi, Tomoko
A1  - Date, Kenji
A1  - Naitoh, Tomomichi
A1  - Suwaki, Hiroshi
SP  - 67
EP  - 74
VL  - 37
IS  - 1
N2  - In 1980s, abuse and dependence of BRON-W syrup (cough suppressant), which contains methylephedrine, dihydrocodeine, chlorpheniramine and caffeine, were prevalent in Japan. Pharmacological and clinical studies suggest that methylephedrine and dihydrocodeine cause dependence. Although BRON-L syrup, newly modified cough suppressant contains only chlorpheniramine and caffeine, there still are abuse and dependence of this drug. In this report, three cases of BRON-L syrup abuse are demonstrated. All cases started using BRON-L syrup in the late teens in their peer groups, and dropped out from school. Case 1 misused only BRON-L syrup, but case 2 and 3 were multi-drug abusers (case 2: amphetamine, cocaine, and marijuana, case 3: solvent, alcohol, bromovalerylurea), and had kept in tough with the peer groups. Case 2 and 3 hospitalized more than 2 times. Withdrawal symptoms, such as headache, insomnia, and irritability were mild and improved in a few weeks after drug use was stopped. These findings suggest that 1) psychosocial backgrounds of these cases are in common with those of BRON-W syrup abusers, but 2) the clinical course and prognosis of multi-drug abusers are different from the BRON single abuser, 3) chlorpheniramine and caffeine possibly cause dependence, 4) abusers are likely to choose BRON brand although two main dependence-producing constituents are removed from it now. Therefore, prevention and care of BRON-L abusers requires both psychosocial and pharmacological aspects.<p /> <p>Language: ja</p>
LA  - ja
SN  - 1341-8963
UR  - http://dx.doi.org/
ID  - ref1
ER  -