TY  - JOUR
PY  - 1999//
TI  - Is there a genetic basis for the deposition of beta-amyloid after fatal head injury?
JO  - Cellular and molecular neurobiology
A1  - Graham, D. I.
A1  - Gentleman, S. M.
A1  - Nicoll, J. A.
A1  - Royston, M. C.
A1  - McKenzie, J. E.
A1  - Roberts, G. W.
A1  - Mrak, R. E.
A1  - Griffin, W. S.
SP  - 19
EP  - 30
VL  - 19
IS  - 1
N2  - 1. Alzheimer's disease is a heterogeneous disorder that may be caused by genetic or environmental factors or by a combination of both. Abnormalities in chromosomes 1, 14, and 21 have all been implicated in the pathogenesis of the early-onset form of the disease, while the epsilon 4 allele of the apolipoprotein E gene (on chromosome 19) is now recognized as a risk factor for early- and late-onset sporadic and familial Alzheimer's disease. 2. The best-established environmental trigger for the disease is a head injury, based on epidemiological and neuropathological evidence. Approximately 30% of patients who die after a single episode of severe head injury show intracerebral deposition of beta-amyloid protein (A beta), a protein that is thought to be central to the pathogenesis of Alzheimer's disease. 3. Recent studies have revealed an over-representation of the apoE epsilon 4 allele in those head-injured patients displaying A beta pathology, thus providing the first evidence for a link between a genetic susceptibility (apoE epsilon 4) and an environmental trigger (head injury) in the development of Alzheimer-type pathology.<p /> <p>Language: en</p>
LA  - en
SN  - 0272-4340
UR  - http://dx.doi.org/
ID  - ref1
ER  -