TY  - JOUR
PY  - 2003//
TI  - Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour
JO  - European Neuropsychopharmacology
A1  - Leppamaki, Sami
A1  - Partonen, Timo
A1  - Vakkuri, Olli
A1  - Lonnqvist, Jouko
A1  - Partinen, Markku
A1  - Laudon, Moshe
SP  - 137
EP  - 145
VL  - 13
IS  - 3
N2  - This study aimed to explore the effects of melatonin on sleep, waking up and well being in subjects with varying degrees of seasonal or weather-associated changes in mood and behaviour. Fifty-eight healthy adults exhibiting subsyndromal seasonal affective disorder (s-SAD) and/or the negative or positive type of weather-associated syndrome (WAS) were randomised to either 2 mg of sustained-release melatonin or placebo tablets 1-2 h before a desired bedtime for 3 weeks. Outcome measures were changes from baseline in sleep quality, sleepiness after waking, atypical depressive symptoms and health-related quality of life by week three. Early morning salivary melatonin concentrations were measured at baseline and treatment cessation in all subjects. Melatonin administration significantly improved the quality of sleep (P=0.03) and vitality (P=0.02) in the subjects with s-SAD, but attenuated the improvement of atypical symptoms and physical parameters of quality of life compared to placebo in the subjects with WAS, positive type.<p /> <p>Language: en</p>
LA  - en
SN  - 0924-977X
UR  - http://dx.doi.org/
ID  - ref1
ER  -