TY  - JOUR
PY  - 1998//
TI  - Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior
JO  - Developmental neuroscience
A1  - King, B. H.
A1  - Cromwell, H. C.
A1  - Lee, H. T.
A1  - Behrstock, S. P.
A1  - Schmanke, T.
A1  - Maidment, N. T.
SP  - 180
EP  - 187
VL  - 20
IS  - 2-3
N2  - Self-injurious behavior occurring in persons with severe mental retardation is a clinically significant and poorly understood problem. Multiple neurotransmitter systems have been implicated in the pathogenesis of this behavior, particularly dopaminergic, opioidergic, and serotonergic systems. Pemoline, a central stimulant, administered systemically at high doses reliably produces self-biting behavior in the rat. The systemic bolus of pemoline produces sustained neostriatal levels of pemoline for over 24 h in a continuous infusion paradigm. Studies of the effect of cortical lesions on pemoline-mediated behaviors reveal that cortical damage, as is common in profound mental retardation, lowers the threshold for pemoline-induced self-biting behavior. Data from the corticostriatal slice suggests that sustained exposure to pemoline produces a shift in N-methyl-D-aspartate receptor-mediated responses rendering them more susceptible to dopaminergic enhancement. Thus, dopaminergic and glutamatergic interactions appear to play an important role in the development and expression of self-biting in the pemoline model.<p /> <p>Language: en</p>
LA  - en
SN  - 0378-5866
UR  - http://dx.doi.org/
ID  - ref1
ER  -