TY  - JOUR
PY  - 1998//
TI  - ECG changes and plasma concentrations of propafenone and its metabolites in a case of severe poisoning
JO  - Journal of toxicology - clinical toxicology
A1  - Fonck, K.
A1  - Haenebalcke, C.
A1  - Hemeryck, A.
A1  - Belpaire, F.
A1  - Jordaens, L.
A1  - Calle, Paul
A1  - Buylaert, W.
SP  - 247
EP  - 251
VL  - 36
IS  - 3
N2  - Case report: Propafenone is a class IC antiarrhythmic agent metabolized into two major metabolites, 5-hydroxypropafenone and N-depropylpropafenone. The potency of 5-hydroxypropafenone to block fast sodium channels is comparable to that of its parent. We report the positive correlation between plasma concentrations and electrocardiographic changes in a patient with severe oral self-poisoning. Serial ECG changes were measured and plasma concentrations were determined by high-performance liquid chromatography. The initial plasma concentrations of propafenone were in the toxic range and correlated with the widening of the QRS-complex. The slow decline in concentration during this first phase might relate to saturation of the isoenzyme CYP2D6. The half-life of propafenone, calculated from the second phase, was approximately 3 hours, defining the patient as a fast metabolizer. The initial concentrations of the metabolite N-depropylpropafenone were surprisingly higher than those of 5-hydroxypropafenone which may also be due to saturation of CYP2D6.<p /> <p>Language: en</p>
LA  - en
SN  - 0731-3810
UR  - http://dx.doi.org/
ID  - ref1
ER  -