TY - JOUR PY - 1998// TI - Massive sulfasalazine and paracetamol ingestion causing acidosis, hyperglycemia, coagulopathy, and methemoglobinemia JO - Journal of toxicology - clinical toxicology A1 - Dunn, R. J. SP - 239 EP - 242 VL - 36 IS - 3 N2 - Case reports: Reports of acute toxicity following sulfasalazine ingestion are rare. A case of an acute ingestion of sulfasalazine 50 g and paracetamol 50 g resulting in severe lactic acidosis, seizures, coagulopathy, hyperglycemia, ketosis, and methemoglobinemia is reported. Despite the ingestion of a large amount of paracetamol with serum paracetamol 5486 nmol/L (844 mg/L), significant hepatotoxicity did not occur. The patient recovered fully following administration of intravenous N-acetylcysteine, methylene blue, sodium bicarbonate, and supportive therapy.
Language: en
LA - en SN - 0731-3810 UR - http://dx.doi.org/ ID - ref1 ER -