TY  - JOUR
PY  - 2011//
TI  - Astrocytic Hypertrophy in Anterior Cingulate White Matter of Depressed Suicides
JO  - Neuropsychopharmacology
A1  - Torres-Platas, Susana G.
A1  - Hercher, Christa
A1  - Davoli, Maria Antonietta
A1  - Maussion, Gilles
A1  - Labonté, Benoit
A1  - Turecki, Gustavo
A1  - Mechawar, Naguib
SP  - 2650
EP  - 2658
VL  - 36
IS  - 13
N2  - Increasing evidence suggests that cortical astrocytic function is disrupted in mood disorders and suicide. The fine neuroanatomy of astrocytes, however, remains to be investigated in these psychiatric conditions. In this study, we performed a detailed morphometric analysis of 3D-reconstructed gray and white matter astrocytes in Golgi-impregnated anterior cingulate cortex (ACC) samples from depressed suicides and matched controls. Postmortem ACC samples (BA24) from 10 well-characterized depressed suicides and 10 matched sudden-death controls were obtained from the Quebec Suicide Brain Bank. Golgi-impregnated protoplasmic astrocytes (gray matter, layer VI) and fibrous astrocytes (adjacent white matter) were reconstructed, and their morphometric features were analyzed using the Neurolucida software. For each cell, the soma size as well as the number, length, and branching of processes were determined. The densities of thorny protrusions found along the processes of both astrocytic subtypes were also determined. Protoplasmic astrocytes showed no significant difference between groups for any of the quantified parameters. However, fibrous astrocytes had significantly larger cell bodies, as well as longer, more ramified processes in depressed suicides, with values for these parameters being about twice as high as those measured in controls. These results provide the first evidence of altered cortical astrocytic morphology in mood disorders. The presence of hypertrophic astrocytes in BA24 white matter is consistent with reports suggesting white matter alterations in depression, and provides further support to the neuroinflammatory theory of depression.Neuropsychopharmacology advance online publication, 3 August 2011; doi:10.1038/npp.2011.154.<p />  <p>Language: en</p>
LA  - en
SN  - 0893-133X
UR  - http://dx.doi.org/10.1038/npp.2011.154
ID  - ref1
ER  -