TY  - JOUR
PY  - 2011//
TI  - Effects of alcohol on highway driving in the STISIM driving simulator
JO  - Human psychopharmacology
A1  - Mets, Monique Anna Johanna
A1  - Kuipers, Esther
A1  - Senerpont Domis, Lieke M.
A1  - Leenders, Maartje
A1  - Olivier, Berend
A1  - Verster, Joris Cornelis
SP  - 434
EP  - 439
VL  - 26
IS  - 6
N2  - OBJECTIVE: The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo. METHODS: Twenty-seven healthy young adults (14 men and 13 women; mean age (SD) = 22.8 (1.4)) participated in this randomized, single-blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo-alcohol. In each condition, subjects completed a 100-km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test. RESULTS: Alcohol produced dose-dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo (p < 0.05). Subjective driving assessments were in line with the objective driving measurements. CONCLUSION: The STISIM highway driving simulator test is able to differentiate dose-dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research. Copyright © 2011 John Wiley & Sons, Ltd.<p />  <p>Language: en</p>
LA  - en
SN  - 0885-6222
UR  - http://dx.doi.org/10.1002/hup.1226
ID  - ref1
ER  -