TY  - JOUR
PY  - 2011//
TI  - Conditioned Tolerance to the Effects of Alcohol on Inhibitory Control in Humans
JO  - Alcohol and alcoholism
A1  - Birak, Kulbir Singh
A1  - Higgs, Suzanne
A1  - Terry, Philip
SP  - 686
EP  - 693
VL  - 46
IS  - 6
N2  - AIMS: To test whether the repeated consumption of alcohol in a particular environment leads to the emergence of a context-specific conditioned compensatory response (CCR) that can counter alcohol's impairment of inhibitory processes. METHODS: Twenty-four participants consumed an alcoholic drink (males: 0.65 g/kg; females: 0.57 g/kg) in one context on three sessions and a matched placebo drink in a different context on three other sessions. At test, participants were split into two groups and consumed a novel alcoholic drink either in the context previously paired with alcohol or the placebo-paired context. On all sessions, participants were tested on two computer-based tasks that measured response inhibition: an affective go/no-go task and a stop-signal task (SST). RESULTS: Over the conditioning trials, tolerance developed to alcohol's disinhibitory effects on the go/no-go task; moreover, on the test for conditioned responding, performance was less impaired for participants in the alcohol-paired versus the placebo-paired context. No tolerance was evident on the SST, and no CCR. CONCLUSION: Repeated consumption of alcohol in a particular environment can lead to the emergence of a context-specific CCR that counters some of alcohol's disinhibitory effects. Therefore, consuming alcohol in an unfamiliar context might produce stronger disinhibitory effects than would be apparent in a familiar drinking environment.<p />  <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/10.1093/alcalc/agr084
ID  - ref1
ER  -