TY  - JOUR
PY  - 1991//
TI  - Effect of alcohol on blood levels of branched-chain alpha-keto acids in male Wistar rats
JO  - Alcohol and alcoholism
A1  - Dominicus, D. A.
A1  - Todoriki, H.
A1  - Ariizumi, M.
A1  - Akamatsu, T.
SP  - 597
EP  - 603
VL  - 26
IS  - 5-6
N2  - The effect of oral alcohol administration on branched-chain alpha-keto acids was studied in Wistar rats. Rats were divided into alcohol loading groups 1 (ethanol single daily dose: 2.5 g/kg body wt for 14 days) and 2 (ethanol dose: 5 g/kg body wt), and a pair-fed control group (isocaloric glucose and food equal to the amount taken by group 1 the previous day). Branched-chain alpha-keto acids, other alpha-keto acids and amino acids were analysed using high-performance liquid chromatography. Results showed a significant body weight increase in the alcohol loading groups. Concentrations of branched-chain amino acids and keto acids were significantly increased in the alcohol-treated groups. The blood levels of methionine, threonine, alanine and glutamic acid were also increased by alcohol administration. Blood levels of taurine and ornithine, however, showed a significant decrease in the alcohol-treated groups. These results show that alcohol increases the blood levels of branched-chain keto acids and branched-chain amino acids.<p /> <p>Language: en</p>
LA  - en
SN  - 0735-0414
UR  - http://dx.doi.org/
ID  - ref1
ER  -