TY  - JOUR
PY  - 1991//
TI  - Alcohol abusers exhibit a higher IgA response to acetaldehyde-modified proteins
JO  - Alcohol and alcoholism supplement
A1  - Worrall, S.
A1  - De Jersey, J.
A1  - Shanley, B. C.
A1  - Wilce, P. A.
SP  - 261
EP  - 264
VL  - 1
IS  - 
N2  - In the present study we have used an enzyme-linked immunosorbent assay to measure the immunoreactivity towards acetaldehyde-modified proteins in plasma from alcoholics, patients with non-alcoholic liver disease and control social drinkers. All three groups showed a response to modified proteins when total immunoglobulin binding was measured. However, when the assay was modified such that class-specific immunoglobulin binding was measured, it was found that the alcoholic response had a significantly greater immunoglobulin A component than patients with non-alcoholic liver disease or controls who were social drinkers. Thus measurement of IgA binding to acetaldehyde-modified proteins may be a marker for alcohol abuse.<p /> <p>Language: en</p>
LA  - en
SN  - 1358-6173
UR  - http://dx.doi.org/
ID  - ref1
ER  -