TY  - JOUR
PY  - 2012//
TI  - The brain-derived neurotrophic factor gene in suicidal behaviour: a meta-analysis
JO  - International journal of neuropsychopharmacology
A1  - Zai, Clement C.
A1  - Manchia, Mirko
A1  - De Luca, Vincenzo
A1  - Tiwari, Arun K.
A1  - Chowdhury, Nabilah I.
A1  - Zai, Gwyneth C.
A1  - Tong, Ryan P.
A1  - Yilmaz, Zeynep
A1  - Shaikh, Sajid A.
A1  - Strauss, John
A1  - Kennedy, James L.
SP  - 1037
EP  - 1042
VL  - 15
IS  - 8
N2  - Suicide is a prominent public health problem. Its aetiology is complex, and the brain-derived neurotrophic factor (BDNF) has been implicated. We performed the first meta-analysis of the functional BDNF marker Val66Met (rs6265, 196G>A) in suicidal behaviour using data from 11 previously published samples plus our present sample (total n=3352 subjects, 1202 with history of suicidal behaviour. The meta-analysis including all 12 studies showed a trend for the Met-carrying genotypes and Met allele conferring risk for suicide (random-effects model p=0.096; ORMet-carrier=1.13, 95% CI 0.98-1.30, and random-effects model p=0.032; ORMet=1.16, 95% CI 1.01-1.32, respectively). Furthermore, we found the Met allele and the Met allele-carrying genotypes to be associated with history of suicide attempt (eight studies; allelic meta-analysis - random-effects model: p=0.013; fixed-effects model: p=0.006; genotypic meta-analysis - random-effects model: p=0.017; fixed-effects model: p=0.008). Taken together, the results from our study suggest that BDNF Val66Met is involved in suicidality. Further studies are required to elucidate its role in suicidal behaviour.<p />  <p>Language: en</p>
LA  - en
SN  - 1461-1457
UR  - http://dx.doi.org/10.1017/S1461145711001313
ID  - ref1
ER  -