TY  - JOUR
PY  - 2011//
TI  - The effects of donepezil on computer-simulated driving ability among healthy older adults: a pilot study
JO  - Journal of clinical psychopharmacology
A1  - Rapoport, Mark J.
A1  - Weaver, Bruce
A1  - Kiss, Alex
A1  - Zucchero Sarracini, Carla
A1  - Moller, Henry
A1  - Herrmann, Nathan
A1  - Lanctôt, Krista
A1  - Murray, Brian
A1  - Bedard, Michel
SP  - 587
EP  - 592
VL  - 31
IS  - 5
N2  - The purpose of the present pilot study was to examine the effect of donepezil on simulated driving among healthy older adults. Twenty participants with a mean age of 72 years were randomized to take 5 mg of donepezil or placebo for 2 weeks. All participants were assessed at baseline and 2 weeks later on measures of attention, global cognition, and simulated driving on the York driving simulator. Driving measures included speed deviation, deviation of road position, reaction time to wind gusts, and collisions. Groups were compared using analysis of covariance, controlling for baseline values. There were no differences between the groups on attentional measures, number of collisions, or composite simulator measures. The placebo group fared approximately 0.5 second better in reaction time to wind gusts and showed a nonsignificant tendency toward less deviation of road position, compared with the donepezil group. This analysis does not support the use of donepezil to extend the period of safe driving among older adults, but further study is needed regarding its role among patients with cognitive disorders.<p />  <p>Language: en</p>
LA  - en
SN  - 0271-0749
UR  - http://dx.doi.org/10.1097/JCP.0b013e31822bb1ba
ID  - ref1
ER  -