TY  - JOUR
PY  - 1991//
TI  - Neuroleptic malignant syndrome: a complication of neuroleptics and cocaine abuse
JO  - Psychiatric quarterly
A1  - Akpaffiong, M. J.
A1  - Ruiz, P.
SP  - 299
EP  - 309
VL  - 62
IS  - 4
N2  - One hundred and sixty psychiatric patients on Neuroleptics, with and without a history of substance abuse were daily monitored in order to establish the incidence of neuroleptic malignant syndrome in these two groups. Four (5.1%) of the cocaine abusers and none of the non-cocaine abusers developed neuroleptic malignant syndrome when treated with neuroleptics. Thus we argue that psychiatric patients with a history of cocaine abuse may be more at risk of developing neuroleptic malignant syndrome when treated with neuroleptics, possibly associated with the blockade of dopamine (D2-receptors) by neuroleptics and the activation of dopamine/5-HT receptors by cocaine-induced dopamine.<p /> <p>Language: en</p>
LA  - en
SN  - 0033-2720
UR  - http://dx.doi.org/
ID  - ref1
ER  -