TY  - JOUR
PY  - 1980//
TI  - Studies on inhalation toxicity of 2-propanol
JO  - Drug and chemical toxicology
A1  - Laham, S.
A1  - Potvin, M.
A1  - Schrader, K.
A1  - Marino, I.
SP  - 343
EP  - 360
VL  - 3
IS  - 4
N2  - Biological effects of a single exposure to moderate or high concentrations of 2-propanol were investigated in Sprague-Dawley rats. Acute toxicity (LC50, t:8 hours) of this widely used solvent was determined and found to be 19000 ppm (17380-20760 ppm) for females and 22500 ppm (19200-26400 ppm) for males. Determination of blood levels of 2-propanol and its metabolite, acetone, was carried out during and after a single 4-hour exposure (Concentration range: 500 to 8000 ppm). The amount of acetone and 2-propanol was directly related to the various air concentrations of alcohol inhaled. Increase of exposure time to 8 hours enhanced considerably the amount of blood acetone which could be determined even 20 hours after exposure. These findings indicate a slow conversion of this alcohol to acetone which can be used as biochemical indicator to exposure. Histopathological examination of rats exposed to high levels of 2-propanol shows typical lesions of chemical pneumonitis and pulmonary edema accompanied by foamy vacuolization of liver cells and severe focal cytoplasmic degradation.<p /> <p>Language: en</p>
LA  - en
SN  - 0148-0545
UR  - http://dx.doi.org/10.3109/01480548009030125
ID  - ref1
ER  -