TY - JOUR PY - 1990// TI - Acute polyneuropathy after malathion poisoning JO - Acta neurologica Belgica A1 - Monje Argiles, A. A1 - Lison, D. A1 - Lauwerys, R. A1 - Mahieu, P. A1 - Brucher, J. M. A1 - Van den Bergh, P. SP - 190 EP - 199 VL - 90 IS - 4 N2 - We report a patient in whom intoxication with a commercial preparation of malathion led to a severe acute cholinergic crisis, protracted cardiac arrhythmias, an acute respiratory distress syndrome, and an acute sensorimotor axonal polyneuropathy. The occurrence of the polyneuropathy was associated with a novel malathion transformation product, S-(1-ethoxycarbonyl, 2-isopropoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate (isopropylmalathion), an impurity present in the pesticide residue. The role of isopropylmalathion in the pathophysiology of the polyneuropathy remains to be determined.

Language: en

LA - en SN - 0300-9009 UR - http://dx.doi.org/ ID - ref1 ER -