TY - JOUR PY - 1982// TI - Prediction of the efficacy of hemoperfusion and hemodialysis in severe poisoning JO - Archives of toxicology, supplement A1 - Verpooten, G. A. A1 - De Broe, M. E. SP - 304 EP - 306 VL - 5 IS - N2 - The pharmacokinetics of nine drugs were studied in 13 severely intoxicated patients treated with combined hemoperfusion-hemodialysis. Five drugs (phenobarbital, methylphenobarbital, amobarbital, meprobamate, thallium) showed one-compartment kinetics. For two drugs (secobarbital, methaqualone) however a two-compartment model had to be accepted. For the former group a one-compartment linear model can be used to predict the efficacy of treatment and to calculate the optimal duration of treatment.
Language: en
LA - en SN - 0171-9750 UR - http://dx.doi.org/ ID - ref1 ER -