TY  - JOUR
PY  - 2011//
TI  - Unmasking Sex-Based Disparity in Neuronal Metabolism
JO  - Current pharmaceutical design
A1  - Manole, Mioara D.
A1  - Tehranian-Depasquale, Roya
A1  - Du, Lina
A1  - Bayir, Hulya
A1  - Kochanek, Patrick Michael
A1  - Clark, Robert S. B.
SP  - 3854
EP  - 3860
VL  - 17
IS  - 35
N2  - Both classic and emerging literature point to sex-based disparity in neuronal metabolism. While detectable under baseline conditions, this phenomenon appears to be exaggerated or sometimes unmasked in neurons by cellular stress. A complex sex-dependent response to nutrient deprivation, excitotoxicity, oxidative/nitrositive stress, oxygen-glucose deprivation, and chemical toxicity has been observed in neurons in vitro, as well as after various insults including ischemic or traumatic brain injury in vivo. Importantly, sex-based disparity in response to diverse therapeutics has been seen in neurons in culture, contemporary animal models of brain injury, and in human disease. These have clear implications for pharmacological design of therapeutics targeting central nervous system diseases involving both males and females, and preclinical testing of promising agents.<p /> <p>Language: en</p>
LA  - en
SN  - 1381-6128
UR  - http://dx.doi.org/
ID  - ref1
ER  -