TY  - JOUR
PY  - 1983//
TI  - A comparison of some psychological and physiological effects exerted by zetidoline (DL308) and by oxazepam
JO  - Psychopharmacology
A1  - Herbert, M.
A1  - Standen, P. J.
A1  - Short, A. H.
A1  - Birmingham, A. T.
SP  - 335
EP  - 339
VL  - 81
IS  - 4
N2  - In a double-blind, balanced crossover study, eight healthy male volunteers ingested either DL-308 (10 mg), DL-308 (20 mg), oxazepam (30 mg) or placebo. Subjective estimates of coordination and anxiety, objective performance measurements and cardiovascular measurements were taken at 1, 3, 5 and 8 h after ingestion. DL-308 (20 mg) exerted a strong sedative effect as judged by self-reported coordination scores and performance on logical reasoning and reaction time tests. The effect was evident almost immediately and, on the coordination and reasoning tests, lasted up to 8 h following ingestion. Attention is drawn to the need to extend performance testing in order to maximise test sensitivity. No drug had any consistent or strong influence on cardiovascular measures.<p /> <p>Language: en</p>
LA  - en
SN  - 0033-3158
UR  - http://dx.doi.org/
ID  - ref1
ER  -