TY  - JOUR
PY  - 1983//
TI  - Methadone plasma levels and persistent drug abuse in high dose maintenance patients
JO  - Substance and alcohol actions/misuse
A1  - Tennant, F. S.
A1  - Rawson, R. A.
A1  - Cohen, A.
A1  - Tarver, A.
A1  - Clabough, D.
SP  - 369
EP  - 374
VL  - 4
IS  - 5
N2  - Methadone maintenance patients who maintained on a high daily dose were divided into good performers and poor performers based on whether they demonstrated persistent use of heroin, non-prescription diazepam, and/or excessive alcohol consumption. Mean methadone plasma levels 24 hours after an oral dose of 80 mg were found to be 410.4 ng/ml in good performers compared to 101.8 ng/ml in poor performers (P less than .05). Seven of nine (77.8%) poor compared to two of 15 (13.3%) good performers had 24-hour methadone plasma levels under 50 ng/ml (P less than .01). High dose methadone patients who show evidence of persistent drug or alcohol abuse should have their 24-hour methadone plasma level determined to help assess whether the patient should receive more methadone or find an alternative treatment.<p /> <p>Language: en</p>
LA  - en
SN  - 0191-8877
UR  - http://dx.doi.org/
ID  - ref1
ER  -