TY - JOUR PY - 2011// TI - Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor JO - Translational psychiatry A1 - Radtke, K. M. A1 - Ruf, M. A1 - Gunter, H. M. A1 - Dohrmann, K. A1 - Schauer, M. A1 - Meyer, A. A1 - Elbert, T. SP - e21 EP - e21 VL - 1 IS - online N2 - Prenatal exposure to maternal stress can have lifelong implications for psychological function, such as behavioral problems and even the development of mental illness. Previous research suggests that this is due to transgenerational epigenetic programming of genes operating in the hypothalamic-pituitary-adrenal axis, such as the glucocorticoid receptor (GR). However, it is not known whether intrauterine exposure to maternal stress affects the epigenetic state of these genes beyond infancy. Here, we analyze the methylation status of the GR gene in mothers and their children, at 10-19 years after birth. We combine these data with a retrospective evaluation of maternal exposure to intimate partner violence (IPV). Methylation of the mother's GR gene was not affected by IPV. For the first time, we show that methylation status of the GR gene of adolescent children is influenced by their mother's experience of IPV during pregnancy. As these sustained epigenetic modifications are established in utero, we consider this to be a plausible mechanism by which prenatal stress may program adult psychosocial function. Keywords: epigenetics; glucocorticoid receptor; hypothalamic-pituitary-adrenal axis; intimate partner violence; methylation; prenatal stress Correspondence: Professor T Elbert, Department of Psychology, University of Konstanz and Center for Psychiatry Reichenau, 78457 Konstanz, Germany. E-mail: (thomas.elbert@uni-konstanz.de); Professor A Meyer, Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany. E-mail: (axel.meyer@uni-konstanz.de)

LA - SN - 2158-3188 UR - http://dx.doi.org/10.1038/tp.2011.21 ID - ref1 ER -