TY  - JOUR
PY  - 1984//
TI  - Adverse effects of single therapeutic doses of diazepam on performance in normal geriatric subjects: relationship to plasma concentrations
JO  - Psychopharmacology
A1  - Pomara, N.
A1  - Stanley, B.
A1  - Block, R.
A1  - Guido, J.
A1  - Russ, D.
A1  - Berchou, R.
A1  - Stanley, M.
A1  - Greenblatt, D. J.
A1  - Newton, R. E.
A1  - Gershon, S.
SP  - 342
EP  - 346
VL  - 84
IS  - 3
N2  - Elderly normal volunteers (N = 12, mean age 70.4 years) were administered placebo or diazepam 2.5, 5, 10 mg in four consecutive sessions separated by at least a 1-week interval. Memory and psychomotor performance and plasma diazepam concentrations were assessed at baseline and at 1 and 3 h following drug administration. Significant impairments were found in response to all doses of diazepam. The maximum impairment occurred at 1 h, which coincided with the highest plasma concentration of the drug.<p /> <p>Language: en</p>
LA  - en
SN  - 0033-3158
UR  - http://dx.doi.org/
ID  - ref1
ER  -