TY - JOUR PY - 1974// TI - Inert gas narcosis, the high pressure neurological syndrome, and the critical volume hypothesis JO - Science A1 - Miller, K. W. SP - 867 EP - 869 VL - 185 IS - 4154 N2 - The hypothesis that general anesthesia or pressure-induced convulsions occur when a hydrophobic region is expanded or compressed, respectively, by critical amounts is consistent with recent data obtained with mice. Calculations show that anesthesia occurs at an expansion of 1.1 percent and convulsions at a compression of 0.85 percent, the latter site of action being more compressible.
Language: en
LA - en SN - 0036-8075 UR - http://dx.doi.org/ ID - ref1 ER -