TY  - JOUR
PY  - 2012//
TI  - Self-referential thinking, suicide, and function of the cortical midline structures and striatum in mood disorders: Possible implications for treatment studies of mindfulness-based interventions for bipolar depression
JO  - Depression research and treatment
A1  - Marchand, William R.
SP  - 246725
EP  - 246725
VL  - 2012
IS  - online
N2  - Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, and studies of these approaches for bipolar disorder are warranted. The aim of this paper is to provide a conceptual background for such studies by reviewing key findings from diverse lines of investigation. Results of that review indicate that cortical midline structures (CMS) appear to link abnormal self-referential thinking to emotional dysregulation in mood disorders. Furthermore, CMS and striatal dysfunction may play a role in the neuropathology underlying suicide-related thoughts and behaviors. Thus, combining studies of mindfulness interventions targeting abnormal self-referential thinking with functional imaging of CMS and striatal function may help delineate the neurobiological mechanisms of action of these treatments.<p />  <p>Language: en</p>
LA  - en
SN  - 2090-1321
UR  - http://dx.doi.org/10.1155/2012/246725
ID  - ref1
ER  -