TY  - JOUR
PY  - 1998//
TI  - No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder
JO  - American journal of medical genetics
A1  - Furlong, R. A.
A1  - Ho, L.
A1  - Rubinsztein, J. S.
A1  - Walsh, C.
A1  - Paykel, E. S.
A1  - Rubinsztein, D. C.
SP  - 245
EP  - 247
VL  - 81
IS  - 3
N2  - Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.<p /> <p>Language: en</p>
LA  - en
SN  - 0148-7299
UR  - http://dx.doi.org/
ID  - ref1
ER  -