TY  - JOUR
PY  - 1998//
TI  - Predictors of cortisol and 3-methoxy-4-hydroxyphenylglycol responses in the acute aftermath of rape
JO  - Biological psychiatry
A1  - Yehuda, Rachel
A1  - Resnick, Heidi S.
A1  - Schmeidler, J.
A1  - Yang, R. K.
A1  - Pitman, R. K.
SP  - 855
EP  - 859
VL  - 43
IS  - 11
N2  - BACKGROUND: Prospective studies of trauma survivors can provide information about the relationship between rape characteristics and the development of subsequent symptoms. METHODS: The present study examined the relationship of prior assault, rape severity, posttraumatic stress disorder (PTSD) symptoms following rape, and subsequent PTSD diagnosis, to the acute cortisol and 3-methoxy-4-hydroxyphenylglycol (MHPG) response to this traumatic event in 20 women. RESULTS: Women with a history of prior physical or sexual assault showed a significantly attenuated cortisol response to the acute stress of rape compared to women without such a history. MHPG appeared to be associated with injury-related rape characteristics, and symptoms of active avoidance, but not prior history. PTSD status at the 3-month follow-up was predicted by both a prior history of assault and high injury rape, but was not directly predicted by either cortisol or MHPG levels. MHPG and cortisol were not correlated in the sample as a whole, but were correlated among individuals who did not subsequently develop PTSD (p = .04) CONCLUSIONS: The results suggest that different neuroendocrine systems may mediate different components of the response to traumatic stress.<p /> <p>Language: en</p>
LA  - en
SN  - 0006-3223
UR  - http://dx.doi.org/
ID  - ref1
ER  -