TY  - JOUR
PY  - 1998//
TI  - Variations in [3H]imipramine and 5-HT2A but not [3H]paroxetine binding sites in suicide brains
JO  - Psychiatry research
A1  - Rosel, Pilar
A1  - Arranz, B.
A1  - Vallejo, J.
A1  - Oros, M.
A1  - Crespo, J. M.
A1  - Menchón, J. M.
A1  - Navarro, M. A.
SP  - 161
EP  - 170
VL  - 82
IS  - 3
N2  - Both the [3H]imipramine and [3H]paroxetine binding sites and the 5-HT2A receptor were simultaneously determined in frontal cortex, cingulate cortex, hippocampus and amygdala from 17 control subjects and 17 depressed suicide victims. A significant decrease in the maximum binding (Bmax) of [3H]imipramine was observed in the hippocampus of suicide victims as compared to control subjects (160 +/- 25 vs. 328 +/- 52 fmol/mg protein; P = 0.007) without changes in the apparent affinity constant (Kd). Furthermore, a significant decrease in the number of 5-HT2A binding sites, together with a significantly lower Kd, was also observed in the hippocampus of suicides as compared to control subjects (129 +/- 18 vs. 225 +/- 32 fmol/mg protein; P = 0.02 and 0.91 +/- 0.07 vs. 1.38 +/- 0.08 nM, respectively; P = 0.006). [3H]Paroxetine binding did not display modifications between the two groups in either Bmax or Kd from any of the brain regions studied. When all four brain regions were taken together, a down-regulation was noted between presynaptic [3H]imipramine binding and the postsynaptic 5-HT2A receptor (r = -0.40; P = 0.0013) in the control group. This correlation did not appear in the suicide group. No correlation was observed between [3H]paroxetine binding and the 5-HT2A receptor in either control subjects or suicides. Taken together, these results suggest that the 5-HT uptake site measured with [3H]imipramine and the 5-HT2A receptors are reliable markers of serotonergic dysfunction.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/
ID  - ref1
ER  -