TY  - JOUR
PY  - 1975//
TI  - Sex dependent toxicity of four chemicals
JO  - Research communications in chemical pathology and pharmacology
A1  - Toth, B.
A1  - Shimizu, H.
A1  - Sornson, H.
A1  - Issenberg, P.
A1  - Erickson, J.
SP  - 577
EP  - 580
VL  - 10
IS  - 3
N2  - Toxicity investigations were conducted with 4 chemicals: hydrazine, 1,2-dimethylhydrazine di HCl, phenylhydrazine HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine in Swiss mice. Hydrazine and phenylhydrazine HCl were administered daily in drinking water, the former at 0.01% and the latter at 0.001% concentrations. The 1,2-dimethylhydrazine di HCl and Beta-N-(gamma-L(+)-glutamyl)-4-hydroxymethylphenylhydrazine were given as a single subcutaneous injection at 45 mug and 100 mug/gr. body weight basis, respectively. The findings clearly showed that all four chemicals exerted a stronger toxic effect in male than in female mice. It is, therefore, recommended in similar situations to use different doses of chemicals for each sex in the long-term tumorigenesis studies.<p /> <p>Language: en</p>
LA  - en
SN  - 0034-5164
UR  - http://dx.doi.org/
ID  - ref1
ER  -