TY  - JOUR
PY  - 1975//
TI  - Studies on the evaluation of the toxicity of various salts of lead, manganese, platinum, and palladium
JO  - Environmental health perspectives
A1  - Holbrook, D. J.
A1  - Washington, M. E.
A1  - Leake, H. B.
A1  - Brubaker, P. E.
SP  - 95
EP  - 101
VL  - 10
IS  - 
N2  - Preliminary studies have been conducted on various parameters in order to assess the possible and relative toxicities of a number of metallic salts. Upon oral administration in lethal-dose experiments, two soluble Pt4+ salts were more toxic than the other salts tested. Following intraperiotneal injection in lethal-dose experiments, PbCl2 was less toxic than several of the soluble or partially soluble salts of Pt4+, Pd2+, and Mn2+. An intake of a total of approximately 250 mg of Pt4+ per rat in the drinking fluid over a 30-day interval did not affect the activities of aniline hydroxylase and aminopyrine demethylase in rat liver microsomes. In rats receiving soluble Pt4+ salts in the drinking fluid, the highest concentration of Pt was found in the kidney and an appreciiable concentration was found in the liver.<p /> <p>Language: en</p>
LA  - en
SN  - 0091-6765
UR  - http://dx.doi.org/
ID  - ref1
ER  -