TY  - JOUR
PY  - 2011//
TI  - What does the corpus callosum tell us about brain changes in the elderly?
JO  - Expert review of neurotherapeutics
A1  - Di Paola, Margherita
A1  - Caltagirone, Carlo
A1  - Spalletta, Gianfranco
SP  - 1557
EP  - 1560
VL  - 11
IS  - 11
N2  - Evaluation of: Ryberg C, Rostrup E, Paulson OB et al. On behalf of the LADIS study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor impairment: a 3 year follow-up of the LADIS study cohort. J. Neurol. Sci. 307(1-2), 100-105 (2011). The corpus callosum is the largest hemispheric interconnection bundle in the human brain. Its anterior-posterior fiber caliber gradient can help in understanding the pathophysiological mechanisms underlying white matter changes both in old age and dementia. Here, the Leukoaraiosis and Disability (LADIS) study, a longitudinal cohort study, which shows an association between corpus callosum atrophy and cognitive and motor decline in the elderly, provides the possibility to consider the use of multimodal macro-microstructural imaging of corpus callosum as a marker of structural brain changes of physiological and pathological aging.<p /> <p>Language: en</p>
LA  - en
SN  - 1473-7175
UR  - http://dx.doi.org/10.1586/ern.11.130
ID  - ref1
ER  -