TY  - JOUR
PY  - 1976//
TI  - Influence of cannabidiol on delta-9-tetrahydrocannabinol effects
JO  - Clinical pharmacology and therapeutics
A1  - Dalton, W. S.
A1  - Martz, R.
A1  - Lemberger, L.
A1  - Rodda, B. E.
A1  - Forney, R. B.
SP  - 300
EP  - 309
VL  - 19
IS  - 3
N2  - Experiments investigating the possible interaction of tetrahydrocannabinol (THC) and cannabidiol (CBD), two major components of marihuana, were conducted under controlled laboratory conditions in a double-blind manner. In one study, 15 male volunteers were given placebo or 25 mug/kg of THC together with either placebo or 150 mug/kg of CBD by inhalation of the smoke of a single cigarette. All four treatments were assigned to each subject according to a series of Latin-square designs. CBD significantly attenuated the subjective euphoria of THC. Psychomotor impairment due to THC was not significantly altered by the simultaneous administration of CBD, but a trend indicating a decrease in THC-like effects was observed after the combination. When administered alone CBD was inactive for all the parameters measured. In a second study, 8 male subjects were given CBD (0 or 150 mug/kg) by smoke inhalation 30 min before THC (0 or 25 mug/kg) in a second cigarette. In contrast to the simultaneous administration of both drugs, CBD pretreatment did not alter the effects of THC on the parameters observed.<p /> <p>Language: en</p>
LA  - en
SN  - 0009-9236
UR  - http://dx.doi.org/
ID  - ref1
ER  -