TY  - JOUR
PY  - 1976//
TI  - Individual variation in mushroom poisoning induced in the male rate by Cortinarius speciosissimus
JO  - Medical biology
A1  - Nieminen, L.
A1  - Pyy, K.
SP  - 156
EP  - 158
VL  - 54
IS  - 2
N2  - The renal toxicity of a homogenate of Cortinarius speciosissimus was studied in male rats after oral administration of 100, 500 and 1,000 mg of dried mushroom/kg body weight. Great individual variation in response to the mushroom toxins was observed. At high doses (500 mg/kg and 1,000 mg/kg) the percentage of treated animals which showed renal damage did not increase in proportion of the dose. 20--30% of the rats appeared to be resistant to the toxins of C. speciosissimus, even after large doses. However, in those animals which were affected the severity of renal damage was dose-dependent. The great individual variation in the response to C. speciosissimus toxins could be explained by genetic variation.<p /> <p>Language: en</p>
LA  - en
SN  - 0302-2137
UR  - http://dx.doi.org/
ID  - ref1
ER  -