TY  - JOUR
PY  - 2011//
TI  - Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth
JO  - Depression and anxiety
A1  - Jenness M A, Jessica L.
A1  - Hankin Ph D, Benjamin L.
A1  - Abela, John R. Z.
A1  - Young, Jami F.
A1  - Smolen Ph D, Andrew
SP  - 1074
EP  - 1080
VL  - 28
IS  - 12
N2  - Background: Previous research, predominantly with adults, has shown that the serotonin transporter gene (5-HTTLPR) interacts with stress (G × E) to predict depressive symptoms; however, few G × E studies have been conducted with youth using rigorous methods, particularly a prospective design and contextual interview to assess stress. This study examined the interaction between 5-HTTLPR and stress, both chronic and episodic, to predict longitudinal change in depressive symptoms among children and adolescents. Methods: A general community sample of youth (N = 200; 57% girls; mean age: 12.09 years old) was genotyped for 5-HTTLPR (rs 25531) at baseline. They were interviewed via contextual stress procedures to ascertain chronic family stress and episodic stressors and completed depressive symptoms questionnaires at baseline and 6 months later. Results: A significant G × E showed that chronic family stress predicted prospective increases in depressive symptoms over 6 months among youth possessing the high-risk S allele. This G × E was not found for episodic stressors occurring in the last 6 months. There was no moderation by sex or pubertal status. Conclusions: These findings advance knowledge on G × E effects in depression among youth. This is the first study to show that chronic family stress, but not episodic stressors, when ascertained by rigorous stress interview, interacts with 5-HTTLPR to prospectively predict depressive symptoms among children and adolescents. Depression and Anxiety 0:1-7, 2011. © 2011 Wiley Periodicals, Inc.<p />  <p>Language: en</p>
LA  - en
SN  - 1091-4269
UR  - http://dx.doi.org/10.1002/da.20904
ID  - ref1
ER  -