TY  - JOUR
PY  - 1998//
TI  - Clinical studies on three cases of the interval form of carbon monoxide poisoning: serial proton magnetic resonance spectroscopy as a prognostic predictor
JO  - Psychiatry research
A1  - Sakamoto, K.
A1  - Murata, T.
A1  - Omori, M.
A1  - Kimura, H.
A1  - Nishio, M.
A1  - Murata, I.
A1  - Koshino, Y.
A1  - Itoh, S.
A1  - Ishii, Y.
A1  - Isaki, K.
SP  - 179
EP  - 192
VL  - 83
IS  - 3
N2  - Three patients with the interval form of carbon monoxide (CO) poisoning were studied for associations between their clinical courses and serial changes on: (1) MRI; (2) EEG; (3) single photon emission computed tomography with N-isopropyl-p-[123I]iodoamphetamine ([123I]IMP SPECT); and (4) proton magnetic resonance spectroscopy ([1HIMRS) to evaluate their usefulness as prognostic predictors. A hyperintense area on MRI T2-weighted images and a hypointense area on T1-weighted images, appearing in the deep white matter, persisted for a prolonged period even after improvement of the clinical symptoms, and did not become an accurate indicator of clinical evaluation or prognosis. [1H]MRS studies with the volume of interest set in the frontal lobe white matter revealed increases in choline-containing compounds, and reductions of N-acetylaspartate in all cases. These findings normalized in one subclinical case over time. Distinctive findings in the severe cases included increased lactate in two cases showing akinetic mutism, with a difference in prognosis noted according to the degree and period of persistence of this increase. EEG findings were relatively well correlated with clinical symptoms in the early period, with a good correlation no longer consistent after a certain period was exceeded. [123I]IMP SPECT findings did not always reflectclinical symptomatology either. These results indicate that [1H]MRS is the most useful indicator in the clinical evaluation of patients with the interval form of CO poisoning.<p /> <p>Language: en</p>
LA  - en
SN  - 0165-1781
UR  - http://dx.doi.org/
ID  - ref1
ER  -