TY  - JOUR
PY  - 2008//
TI  - Relations between movement disorders and psychopathology under predominantly atypical antipsychotic treatment in adolescent patients with schizophrenia
JO  - European child and adolescent psychiatry
A1  - Gebhardt, Stefan
A1  - Härtling, Fabian
A1  - Hanke, Markus
A1  - Theisen, Frank M.
A1  - von Georgi, Richard
A1  - Grant, Phillip
A1  - Mittendorf, Markus
A1  - Martin, Matthias
A1  - Fleischhaker, Christian
A1  - Schulz, Eberhard
A1  - Remschmidt, Helmut
SP  - 44
EP  - 53
VL  - 17
IS  - 1
N2  - OBJECTIVE: To examine relations between movement disorders (MD) and psychopathological symptoms in an adolescent population with schizophrenia under treatment with predominantly atypical antipsychotics. METHOD: MD symptoms and psychopathology were cross-sectionally assessed in 93 patients (aged 19.6 +/- 2.2 years) using Tardive Dyskinesia Rating Scale (TDRS), Abnormal Involuntary Movement Scale (AIMS), Extrapyramidal Symptom Scale (EPS), Barnes Akathisia Scale (BAS), Brief Psychiatric Rating Scale (BPRS) and the Schedule for Assessment of Negative/Positive Symptoms (SANS/SAPS). RESULTS: All patients with MD symptoms (n = 37; 39.8 %) showed pronounced global psychpathological signs (SANS/SAPS, BPRS: p = 0.026, p = 0.033, p = 0.001) with predominant anergia symptoms (p = 0.005) and inclinations toward higher anxiety- and depression-related symptoms (p = 0.051) as well as increased thought disturbance (p = 0.066). Both negative symptoms and anergia showed trends for positive correlations with tardive dyskinesia (p = 0.068; p = 0.065) as well as significant correlations with parkinsonism symptoms (p = 0.036; p = 0.023). Akathisia symptoms correlated significantly with hostile and suspicious symptoms (p = 0.013). A superfactor-analysis revealed four factors supporting the aforementioned results. CONCLUSION: MD symptoms and psychopathology are in some respects related to each other. Motor symptoms representing on the one hand trait characteristics of schizophrenia might additionally be triggered by antipsychotics and finally co-occur with more residual symptoms within a long-term treatment.<p /> <p>Language: en</p>
LA  - en
SN  - 1018-8827
UR  - http://dx.doi.org/10.1007/s00787-007-0633-0
ID  - ref1
ER  -