TY  - JOUR
PY  - 2012//
TI  - Suicidal Behavior, Smoking, and Familial Vulnerability
JO  - Nicotine and tobacco research
A1  - Scherrer, Jeffrey F.
A1  - Grant, Julia D.
A1  - Agrawal, Arpana
A1  - Madden, Pamela A. F.
A1  - Fu, Qiang
A1  - Jacob, Theodore
A1  - Bucholz, Kathleen K.
A1  - Xian, Hong
SP  - 415
EP  - 424
VL  - 14
IS  - 4
N2  - INTRODUCTION: Smoking is a well-established correlate of suicidal behavior. It is not known if familial risk factors contribute to this association. METHODS: Data were obtained via semistructured interviews with 1,107 twin fathers, 1,919 offspring between ages 12-32 years, and 1,023 mothers. Familial vulnerability to nicotine dependence and suicidal behavior was modeled via father and maternal self-report of these behaviors. Multinomial logistic regression models were computed with and without familial risk factors to estimate the association between offspring ever smoking, regular smoking, nicotine dependence, and a 4-level offspring suicide variable: (a) none, (b) ideation, (c) ideation + plan, and (d) ideation + plan + attempt or ideation + attempt. All models were stratified by gender and adjusted for sociodemographics, familial risk factors including parental suicidal behavior, nicotine dependence, and conduct disorder, and offspring conduct disorder, depression, alcohol abuse/dependence, and illicit drug abuse/dependence. RESULTS: After adjusting for covariates and familial risk factors, ever smoking was not significantly associated with suicidal behavior in males and females. In males, regular smoking was associated with ideation + plan (odds ratio [OR] = 5.47; 95% CI: 1.05-28.60), and in females, regular smoking was associated with ideation + plan + attempt or ideation + attempt. In both genders, nicotine-dependent smoking was associated with ideation + plan + attempt or ideation + attempt (males: OR = 6.59; 95% CI: 1.91-22.70, females: OR = 3.37; 95% CI: 1.25-9.04). Comparison of models with and without familial risk factors indicated that there is no mediation of smoking status and suicidal behavior by familial risk.Conclusions:Smoking and nicotine dependence are correlated with suicidal behaviour. Contributions from familial risk factors did not significantly alter this association.<p />  <p>Language: en</p>
LA  - en
SN  - 1462-2203
UR  - http://dx.doi.org/10.1093/ntr/ntr230
ID  - ref1
ER  -