TY  - JOUR
PY  - 2013//
TI  - Fatal methanol poisoning: Features of liver histopathology
JO  - Toxicology and industrial health
A1  - Akhgari, Maryam
A1  - Panahianpour, Mohammad Hadi
A1  - Bazmi, Elham
A1  - Etemadi-Aleagha, Afshar
A1  - Mahdavi, Amirhossein
A1  - Nazari, Saeed Hashemi
SP  - 136
EP  - 141
VL  - 29
IS  - 2
N2  - Methanol poisoning has become a considerable problem in Iran. Liver can show some features of poisoning after methanol ingestion. Therefore, our concern was to examine liver tissue histopathology in fatal methanol poisoning cases in Iranian population. In this study, 44 cases of fatal methanol poisoning were identified in a year. The histological changes of the liver were reviewed. The most striking features of liver damage by light microscopy were micro-vesicular steatosis, macro-vesicular steatosis, focal hepatocyte necrosis, mild intra-hepatocyte bile stasis, feathery degeneration and hydropic degeneration. Blood and vitreous humor methanol concentrations were examined to confirm the proposed history of methanol poisoning. The majority of cases were men (86.36%). In conclusion, methanol poisoning can cause histological changes in liver tissues. Most importantly in cases with mean blood and vitreous humor methanol levels greater than 127 ± 38.9 mg/dL more than one pathologic features were detected.<p />  <p>Language: en</p>
LA  - en
SN  - 0748-2337
UR  - http://dx.doi.org/10.1177/0748233711427050
ID  - ref1
ER  -