TY - JOUR PY - 2001// TI - Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug? JO - Annals of emergency medicine A1 - Caldicott, D. G. A1 - Kuhn, M. SP - 99 EP - 102 VL - 37 IS - 1 N2 - Gamma-hydroxybutyrate was introduced as an anesthetic agent in the 1960s and is still used in some countries, despite recognized disadvantages. More recently, it has emerged as a popular recreational drug. We report 3 cases of gamma-hydroxybutyrate overdose, the effects of which were reversed by the administration of low-dose intravenous physostigmine. The origins of this regimen and the case for physostigmine as a potential antidote are described.

Language: en

LA - en SN - 0196-0644 UR - http://dx.doi.org/10.1067/mem.2001.111642 ID - ref1 ER -