TY  - JOUR
PY  - 2001//
TI  - Behavioral pharmacological similarities between methylphenidate and cocaine in cocaine abusers
JO  - Experimental and clinical psychopharmacology
A1  - Rush, C. R.
A1  - Baker, R. W.
SP  - 59
EP  - 73
VL  - 9
IS  - 1
N2  - Six human participants with recent histories of cocaine use were trained to discriminate 200 mg oral cocaine hydrochloride. A range of doses of oral cocaine (50-300 mg), methylphenidate (15-90 mg), triazolam (0.125-0.75 mg), and placebo were then tested to determine whether they shared discriminative-stimulus and participant-rated effects with 200 mg cocaine. Cocaine and methylphenidate dose-dependently increased cocaine-appropriate responding, produced prototypical stimulant-like participant-rated drug effects (e.g., increased participant ratings of Drug Liking), and increased heart rate and blood pressure. Triazolam produced low levels of cocaine-appropriate responding and impaired performance. Thus, consistent with previous studies, humans can reliably discriminate oral cocaine. Consistent with in vivo behavioral neuropharmacological data, the discriminative-stimulus, participant-rated, and physiological effects of oral cocaine and methylphenidate were similar.<p /> <p>Language: en</p>
LA  - en
SN  - 1064-1297
UR  - http://dx.doi.org/
ID  - ref1
ER  -