TY  - JOUR
PY  - 2004//
TI  - Death following acute poisoning by moclobemide
JO  - Forensic science international
A1  - Giroud, Christian
A1  - Horisberger, Beat
A1  - Eap, Chin B.
A1  - Augsburger, Marc
A1  - Ménétrey, Annick
A1  - Baumann, Pierre
A1  - Mangin, Patrice
SP  - 101
EP  - 107
VL  - 140
IS  - 1
N2  - A fatality due to ingestion of a reversible inhibitor of monoamine-oxidase A (MAO-A) is reported. Moclobemide is generally considered as a safe drug far less toxic than tricyclic anti-depressants. However, severe intoxications may result from interactions with other drugs and food such as selective serotonin reuptake inhibitors (SSRIs), anti-Parkinsonians of the MAOI-type (e.g. selegiline) or tyramine from ripe cheese or other sources. In the present case, high levels of moclobemide were measured in peripheral blood exceeding toxic values reported so far in the scientific literature. The body fluid concentrations of moclobemide were of 498 mg/l in peripheral whole blood, 96.3 mg/l in urine while an amount of approximately 33 g could be recovered from gastric contents. The other xenobiotics were considered of little toxicological relevance. The victim (male, 48-year-old) had a past history of depression and committed one suicide attempt 2 years before death. Autopsy revealed no evidence of significant natural disease or injury. It was concluded that the manner of death was suicide and that the unique cause of death was massive ingestion of moclobemide.<p /> <p>Language: en</p>
LA  - en
SN  - 0379-0738
UR  - http://dx.doi.org/10.1016/j.forsciint.2003.10.021
ID  - ref1
ER  -